Lysophosphatidylserine receptor GPR34-Gi complex
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8iz4
Q-score: 0.52
Gong W, Liu G, Li X, Wang Y, Zhang X
To Be Published
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Lysops-gpr34-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serine (105 Da, Ligand)
- [(2~{r})-2-oxidanyl-3-phosphonooxy-propyl] octadecanoate (438 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (64 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of Lys05 bound GPR30-Gq complex structure
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xof
Q-score: 0.551
To Be Published
- Lys01 (440 Da, Ligand)
- G protein subunit q (41 kDa, Protein from Homo sapiens)
- Gpr30-gq complex (Complex)
- Nanobody35 (Complex from Lama glama)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr30-gq (Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo-GPR30-Gq complex structure
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xog
Q-score: 0.462
To Be Published
- Scfv16 (Complex from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Gpr30-gq (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of E2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xoh
Q-score: 0.503
To Be Published
- Scfv16 (Complex from synthetic construct)
- Gpr30-g1 (Complex from Homo sapiens)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xoi
Q-score: 0.522
To Be Published
- Scfv16 (Complex from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xoj
Q-score: 0.522
To Be Published
- Scfv16 (Complex from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8tua
Q-score: 0.306
Ravala SK, Adame-Garcia SR, Li S, Chen C, Cianfrocco MA, Gutkind JS, Cash JN, Tesmer JJG
eLife (2024) [ DOI: doi:10.7554/eLife.92822.1 ]
- Inositol-(1,3,4,5)-tetrakisphosphate (500 Da, Ligand)
- Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein (183 kDa, Protein from Homo sapiens)
- Complex of full-length phosphatidylinositol 3,4,5-trisphosphate (pip3)-dependent rac exchanger 1 (p-rex1) bound to inositol 1,3,4,5-tetrakisphosphate (ip4) (183 kDa, Complex from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8j6i
Q-score: 0.443
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8j6l
Q-score: 0.4
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- Svf16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
PhK holoenzyme in inactive state, muscle isoform
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jfk
Q-score: 0.265
Yang X, Zhu M, Lu X, Wang Y, Xiao J
Nat Commun (2024) 15 pp. 2719-2719 [ DOI: doi:10.1038/s41467-024-47049-2 Pubmed: 38548794 ]
- Phosphorylase b kinase regulatory subunit beta (125 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (137 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase, muscle isoform (Complex from Homo sapiens)
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (45 kDa, Protein from Homo sapiens)
- Farnesyl (206 Da, Ligand)